SUMMARY: Lipid Changes in Liver Cancer

    

The article is about the changes of lipid and lipoprotein and the clinical significances in liver cancer.Patients with liver cancer always followed by liver diseases.Liver cancer and chronic influence blood fat level detected that triglyceride level decreased 28.8% in 40 cases with liver cancer.When hepatic inadequacy occured because of liver cancer and chronic liver disease,form,esterification and evacuation of cholesterol were blocked which causes changes of plasma cholesterol level and it is also discovered that serum cholesterol was negative correlated with occurrence and mortality of some cancers.Each protein is influenced by liver disease in a different way and serum lipoprotein concentrations with faster turn-over are more reduced with respect to those with slower turn-over.Serum concentration of apoA-I and apoA-IIwere determind in liver cancer shows significantly low values.

Changes in lipoprotein consists of Metabolism of lipoprotein in liver cancer and Metabolism of High Density Lipoprotein(HDL)and Low Density Lipoprotein(LDL) in liver cancer.Influence of liver cancer on apolipoprotein shows that the reaction of the liver participation converts proapoA-I to the mature apoA-I and also propotion proapoA-I shows tendency towards increace and advance in liver damage.

The liver is a critical organ in fatty acids of metabolism.Fatty acid is also the source of liver triacylglycerol.The extracellular free fattyacids pool in tumor undergoes continuous turn-over,probably utilizing adipose tissue deposits as source and plasma free fatty acids are increased in tumor bearing animals.Possibility that selected changes in the hepatocellular metabolism of long-chain fatty acids may contribute leads to alteration in gene expression and

DNA.Thus the liver plays a vital in the production and clearance of large number of lipoproteins,and its important determinant the plasma levels of various lipids.Serum level of lipid and lipoprotein in liver cancer reflected the condition of liver lipid and lipoprotein metabolism and hepatic cell impairment exactly.(Praveen)